Dr. Gupta is a Member of the Whitehead Institute for Biomedical Research and an Assistant Professor in the Department of Biology at MIT. His laboratory studies the mechanisms underlying cellular differentiation and cell-fate decisions, and how the subversion of these processes contributes to cancer pathobiology. Dr. Gupta received a Bachelor of Science in mathematics from the University of Chicago and a Ph.D. in biology at MIT. He conducted post-doctoral research at the Broad Institute, where he applied innovative genomic approaches to problems in cancer. Dr. Gupta is an expert in the application of genomic methods to cancer, and has contributed to our understanding of cancer metastasis. His research was among the first to show that the pre-existing epigenetic states of cancer cell precursors strongly influence metastatic propensity following neoplastic transformation. Dr. Gupta has also developed methods to identify cancer stem cell (CSC)-selective compounds, and methods to discover and quantitatively model transition rates between cancer cell phenotypic states. His work demonstrated the stochastic bidirectional interconversion between CSCs and non-CSCs, revealing the plasticity of cancer cell states. Currently, his laboratory investigates the molecular and epigenetic mechanisms that regulate normal and cancer stem cell self-renewal and differentiation.
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